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Depression or suicidal thoughts: Any noticeable changes in mood, behavior, or thoughtsespecially those that feel intense or unusualshould be shared with a healthcare provider right away

A sample could show 99% purity by HPLC while still containing problematic contaminants that a different analytical method would detect

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J Neurosci1994 Aug;14(8):5068-76

SURMOUNT-5 also noted that weight loss was approximately 6% lower in men than women in both treatment groups but men on tirzepatide still do very well in absolute terms